Molecular Basis of Life

Overview

The Molecular Basis of Life (BIO1103) is a 20 CAT module that provides a comprehensive introduction to the molecular basis of life from the molecular level through to cells, tissues, and whole organisms. This module broadly covers biochemistry, molecular biology, and energy metabolism in the context of life of earth. The course begins with an introduction to the chemical context of life (elements, compounds, molecules, atoms, bonding and thermodynamics) and biomolecules (amino acids, proteins, nucleic acids, carbohydrates, lipids), to include the molecular and biochemical processes which underpin life on earth (DNA replication, RNA transcription and translation, genetic code and mutation, protein biochemistry, enzyme kinetics, glucose metabolism, metabolism control, and photosynthesis). Students are introduced to basic cell structure and communication to facilitate exploration of life at all levels and in different environmental conditions and allow understanding of the evolutionary scales of biological systems. Students receive practical teaching in key laboratory skills, DNA extraction, amino acid titration, enzyme kinetics, and photosynthesis. Students will be trained in basic laboratory mathematics including molar calculations and key mathematical concepts/theories. Students will also receive teaching in laboratory Health and Safety regulations and will be instructed in Good Laboratory Practice.

Learning Objectives

On successful completion of this module students will be able to:

LO1: Demonstrate knowledge and understanding of the chemistry of life and its application to biological sciences.
LO2: Demonstrate a knowledge and understanding of biodiversity and organismal biology in the context of biochemical processes that govern life on earth.
LO3: Describe and explain the structures, roles and activities of the major biological molecules, sub-cellular components and cell types.
LO4: Develop problem solving skills and the ability to analyse data.
LO5: Develop written communication skills including report writing.
LO6: Develop an understanding of Good Laboratory Practice (GLP), health and safety in the laboratory and ethical practice.
LO7: Demonstrate competence in specific laboratory practical and manipulative skills.
LO8: Demonstrate the ability to work as part of a team and reflect on their role in the team.

Skills

Development of laboratory skills related to molecular biology, biochemistry and energy metabolism as evidenced through practical skills portfolio; report writing; critical and logical analysis of data, peer and self-assessment

Assessment

Class test attendance x 2; practical attendance; Minimum mark of 40% in combined continuous assessment elements