Solid State Pharmaceutical Analysis Methods

Overview

Staff:
Dr P. Nockemann Contribution: 5 Lectures / 3 seminars
TBC Contribution: 7 Lectures / 4 seminars
Prof. Steven J. Bell Contribution: 5 Lectures / 2 seminars
Dr M. Swadzba-Kwasny Contribution: 4 Lectures / 2 seminars
Prof. Ryan Donnelly Contribution: 1 Lecture
Dr Diarmaid Murphy Contribution: 1 Lecture


Summary of Lecture Content:

Week Lectures Lecturer
1 Introduction to the Solid State 1 – Thermodynamics, Polymorphs and Interactions PN
2 Introduction to the Solid State 2 – Physical Properties and Processes TBC
3 Thermal analysis (Isothermal Calorimetry, DSC and TGA) 1 MSK
4 Thermal analysis (Isothermal Calorimetry, DSC and TGA) 2 MSK
5 APPLIED Thermal Analysis (TGA, DSC, & ITC) MSK
6 X-Ray crystallography including Power X-Ray Diffraction 1 PN
7 X-Ray crystallography including Power X-Ray Diffraction 2 PN
8 X-Ray crystallography including Power X-Ray Diffraction 3 PN
9 APPLIED X-ray Diffraction PN
10 Optical and Electron Microscopy (SEM, TEM) 1 TBC
11 Optical and Electron Microscopy (SEM, TEM) 2 TBC
12 Surface area analysis DC
Break
16 Particulate Analysis & Technology DM
17 Measurement of water content (KF, DVS) TBC
18 IR and near-IR spectroscopy SJB
19 APPLIED Infrared Spectroscopy SJB
20 Raman spectroscopy SJB
21 APPLIED Raman Spectroscopy SJB
22 Formulated product analysis- most common formulation RD
23 Data presentation of chemical information: data handling; data processing SJB
24 Solid State NMR spectroscopy MSK
25 Combining Solid State Analytical Techniques 1 TBC
26 Combining Solid State Analytical Techniques 2 TBC
Practicals

Total 24 hrs: 6 x 4hrs practicals

Learning Objectives

At the end of the module the students are expected to:
• Perform enhanced laboratory and instrumentation skills related to solid state characterisation techniques.
• Apply the theoretical background of solid state characterisation techniques to the analysis of pharmaceuticals and related products.
• Apply basic and advanced procedures used in the solid-state characterisation of pharmaceutical and related products.
• Possess practical skills associated with spectroscopic instrumentation and techniques including thermal analysis, X-Ray diffraction techniques, solid-state NMR, IR/Raman spectroscopy, microscopy and analysis of particulate materials.
• Read, understand and assimilate new information and subsume acquired knowledge into a concise format.
• Reflect on experimental outcomes and use this in relation to overcoming analytical method development orientated problems.
• Demonstrate problem solving skills.
• Perform advanced mathematical and statistical manipulation of data.
• Demonstrate effective written and oral communication skills, including preparation and presentation of technical reports based on experimental results.
• Be able to working in a team, through participation in group projects.
• Demonstrate critical thinking through the validation of information (personal and literature data) and the application of theoretical knowledge to practical method development and problem solving.
• Have a sound understanding of advanced analytical techniques and procedures used in the analysis of pharmaceutical and related products.
• Have the practical and related skills required to carry out such techniques/procedures and in the production of appropriate reports.
• Have developed skills to understand and identify suitable technique/s for application to specific pharmaceutical product type.
• Translate theoretical knowledge of the subject into practical methodology and applications.

Skills

• Ability to obtain and record characterisation data using common solid-state techniques.
• Ability to perform data handling, interpretation of results and formulate conclusions.
• Ability to produce written reports utilising IT skills.

Assessment

Assessment:
Examination 70 % (3hr)
Coursework 30 %
Course Requirements:
Coursework submission 100 %
Laboratory Class attendance 100 %
Examination theory Veto 50 %

Both the exam and total coursework elements must be passed at 50%.