Advanced Separation Science (SA)

Overview

STAFF

NAME CONTRIBUTION
Prof. De Lorenzi (Pavia) 3 Lectures
Prof. P Manesiotis Module Coordinator 9 lectures/4 seminars
p.manesiotis@qub.ac.uk

• Summary of Lecture Content:
• Lecture 1: Introduction to separations and chromatography
• Lecture 2: Liquid Chromatography 1
• Lecture 3: Liquid Chromatography 2
• Lecture 4: Liquid Chromatography 3
• Lecture 5: Gas Chromatography
• Lecture 6: TLC/IC
• Lecture 7: Self-Study: Method development and validation
• Lecture 8: Biopharmaceutical Analysis
• Lecture 9: Sample preparation
• Lecture 10: Capillary Electrophoresis 1
• Lecture 11: Self-Study: Capillary Electrophoresis 2
• Lecture 12: Hyphenated analytical techniques

• Summary of Practical Content:
• Workshop 1 & Practical 1: HPLC instrumentation and familiarisation with procedures and software.
• Workshop 2 & Practical 2: HPLC method development.
• Workshop 3 & Practical 3: HPLC method validation and assay of pharmaceutical mixture.
• Workshop 4 & Practical 4: Gas chromatography.

Learning Objectives

• At the end of the module students are expected to be able to:
• Perform enhanced laboratory and instrumentation skills related to modern separation techniques.
• Apply the theoretical background of separation techniques to the analysis of pharmaceuticals, biopharmaceuticals and related products.
• Apply basic and advanced procedures used in the chromatographic analysis of pharmaceuticals, biopharmaceuticals and related products.
• Possess practical skills associated with analytical instrumentation and techniques including HPLC, GC, IC, TLC and CE.
• Read, understand and assimilate new information and subsume acquired knowledge into a concise format.
• Reflect on experimental outcomes and use this in relation to overcoming analytical method development orientated problems.
• Demonstrate problem solving skills.
• Perform advanced mathematical and statistical manipulation of data.
• Demonstrate effective written and oral communication skills, including preparation and presentation of technical reports based on experimental results.
• Be able to work in a team, through participation in group projects.
• Demonstrate critical thinking through the validation of information (personal and literature data) and the application of theoretical knowledge to practical method development and problem solving.

Skills

• Skills Associated With Module:
• Ability to obtain and record relevant analytical data.
• Ability to perform data handling, interpretation of results and formulating conclusions.
• Ability to produce written reports utilising IT skills.

Assessment

ASSESSMENT

Exam session 1st Semester

Assessment Profile:
Element type Element weight (%)
1. Examination (3hrs) 70
2. Coursework 30

Course Requirements:
Coursework submission 100 %
Laboratory Class attendance 100 %
Examination theory Veto 50 %
Both the exam and total coursework elements must be passed at 50%.