Spectroscopic Analysis Methods I

Overview

Summary of Lecture Content:

• Principles of Pharmaceutical Analysis (1)
• Basic spectroscopic principles (1)
• Basic spectroscopic principles (2)
• Ultraviolet spectroscopy
• Fluorescence spectroscopy
• NMR (1)
• NMR (2)
• Applied NMR spectroscopy
• Solid State NMR spectroscopy
• Mass spectrometry (1)
• Mass spectrometry (2)
• Hyphenated analytical techniques

Summary of Practical Content:

• Workshop 1 & Practical 1: UV-Vis and Fluorescence spectroscopy
• Workshop 2 & Practical 2: NMR spectroscopy
• Workshop 3 & Practical 3: Mass spectrometry

Learning Objectives

At the end of the module the students will be able to:

• Describe and compare the fundamental principles and instrumentation of key spectroscopic
techniques used in pharmaceutical analysis, including UV-Vis, fluorescence, NMR, and mass
spectrometry.
• Interpret spectroscopic data to determine structural, compositional, and functional information
about pharmaceutical compounds in both solution and solid-state forms.
• Apply nuclear magnetic resonance (NMR) techniques, including 1D, 2D, and solid-state NMR,
to investigate molecular structure and dynamics in pharmaceutical materials.
• Evaluate the capabilities and limitations of mass spectrometry and hyphenated techniques
(e.g. LC-MS, GC-MS) in pharmaceutical compound identification and quantification.
• Demonstrate practical competence in operating spectroscopic instrumentation and analysing
experimental data through hands-on laboratory and workshop-based activities.
• Critically assess analytical strategies that integrate multiple spectroscopic techniques for
comprehensive pharmaceutical characterisation and problem-solving.

Skills

Skills associated with module:

• Ability to interpret complex spectral data (e.g. NMR, UV-Vis, fluorescence, MS) for structural
elucidation and compound characterisation.
• Competence in the operation and application of advanced spectroscopic and hyphenated
techniques for pharmaceutical analysis.
• Selecting and combining appropriate spectroscopic methods to solve pharmaceutical problems
and support formulation or regulatory decisions.

Assessment

Assessment Profile
Element type Element weight (%)
Coursework 100

Course Requirements:

• Coursework submission 100 %
• Laboratory Class attendance 100 %
• Total coursework elements must be passed at 50%.